Back to Search
Start Over
Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels
- Source :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (5):924-930
- Publisher :
- Elsevier B.V.
-
Abstract
- Polymeric scaffolds formed from synthetic or natural materials have many applications in tissue engineering and medicine, and multiple material properties need to be optimized for specific applications. Recent studies have emphasized the importance of the scaffolds' mechanical properties to support specific cellular responses in addition to considerations of biochemical interactions, material transport, immunogenicity, and other factors that determine biocompatibility. Fibrin gels formed from purified fibrinogen and thrombin, the final two reactants in the blood coagulation cascade, have long been shown to be effective in wound healing and supporting the growth of cells in vitro and in vivo. Fibrin, even without additional growth factors or other components has potential for use in neuronal wound healing in part because of its mechanical compliance that supports the growth of neurons without activation of glial proliferation. This review summarizes issues related to the use of fibrin gels in neuronal cell contexts, with an emphasis on issues of immunogenicity, and considers the potential advantages and disadvantages of fibrin prepared from non-mammalian sources.
- Subjects :
- Central Nervous System
Biocompatibility
Immunogenic
Cell Culture Techniques
Wound healing
Biocompatible Materials
02 engineering and technology
Fibrinogen
Fibrin
Article
Stiffness
03 medical and health sciences
Thrombin
Tissue engineering
In vivo
Materials Testing
medicine
Animals
Humans
Molecular Biology
030304 developmental biology
Neurons
0303 health sciences
biology
Tissue Scaffolds
Chemistry
Immunogenicity
Cell Biology
021001 nanoscience & nanotechnology
3. Good health
Nerve Regeneration
Immunology
biology.protein
Biophysics
0210 nano-technology
Gels
Biomarkers
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 01674889
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Accession number :
- edsair.doi.dedup.....0069cf2a80f78216e121e14621907dce
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2009.01.007