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Heritability of left ventricular structure and function in Caucasian families
- Source :
- European Journal of Echocardiography, European Journal of Echocardiography; Vol 12, European journal of echocardiography, 12(4), 326-332. Oxford University Press
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Aims The aim of this study was to investigate the heritability as well as genetic and environmental correlations of left ventricular (LV) structural and functional traits in complex pedigrees of a Caucasian population. Methods and results We randomly recruited 459 white European subjects from 52 families (50% women; mean age 45 years). LV structure was measured by M-mode and 2D echocardiography and LV function was measured by conventional Doppler and tissue Doppler imaging (TDI). Other measurements included blood pressure, anthropometric, and biochemical measurements. We estimated the heritability of LV traits while adjusting for covariables, including sex, age, body height and weight, systolic and diastolic blood pressures, and heart rate. With full adjustment, heritability of LV mass was 0.23 ( P = 0.025). The TDI-derived mitral annular velocities Ea and Aa showed moderate heritability ( h 2= 0.36 and 0.53, respectively), whereas the mitral inflow A peak had weak heritability ( h 2 = 0.25) and the E peak was not heritable ( h 2 = 0.11). We partitioned the total phenotypic correlation when it reached significance, into a genetic and an environmental component. The genetic correlations were 0.61 between the E and Ea peaks and 0.90 between the A and Aa peaks. Conclusion Our study demonstrated moderate heritability for LV mass as well as the mitral annular Ea and Aa peaks. We also found significant genetic correlations between the E and Ea peaks and between the A and Aa peaks. Our current findings support the ongoing research to map and detect genetic variants that contribute to the variation in LV mass and other LV structural and functional phenotypes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Genotype
Population
Diastole
Blood Pressure
030204 cardiovascular system & hematology
Doppler echocardiography
Doppler imaging
White People
Heritability
03 medical and health sciences
0302 clinical medicine
Internal medicine
Heart rate
medicine
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Systole
10. No inequality
education
education.field_of_study
Anthropometry
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
Echocardiography, Doppler
Phenotype
Blood pressure
Endocrinology
Echocardiography
Population science
Cardiology
Regression Analysis
Left ventricular phenotypes
Female
Hypertrophy, Left Ventricular
Clinical/Original Papers
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 20472412, 20472404, and 15252167
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- European Heart Journal - Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....00604ab0517ac2a40f56f0bfb3f0dcb2
- Full Text :
- https://doi.org/10.1093/ejechocard/jer019