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Calciphylaxis in pediatric end-stage renal disease
- Source :
- Pediatric Nephrology. 20:1776-1780
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- Calciphylaxis is a rare, but life-threatening complication of end-stage renal disease (ESRD) that has been reported mostly in adult patients. The exact etiology is unknown, but the disease is commonly associated with a high calcium-phosphorus product and elevated levels of parathyroid hormone (PTH). We herein review the published reports on calciphylaxis in ESRD patients less than 18 years old and report the case of a patient with severe calciphylaxis who presented with lower extremity pain, muscle tenderness and difficulty in walking. The serum PTH was low, and the calcium-phosphorus product was normal. The diagnosis of calciphylaxis was confirmed by a muscle biopsy. Treatment with low calcium peritoneal dialysate and substitution of calcium-based phosphorus binders with sevelamer (Renagel) was unsuccessful. The patient's clinical condition progressed to extensive soft tissue calcification and ulcerating skin lesions. Nine months after the onset of symptoms, the patient died of cardiopulmonary arrest.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Adolescent
Biopsy
medicine.medical_treatment
Pain
Sevelamer
Peritoneal dialysis
End stage renal disease
Fatal Outcome
Internal medicine
medicine
Humans
Muscle, Skeletal
Skin
Calciphylaxis
Muscle biopsy
medicine.diagnostic_test
business.industry
Phosphorus
medicine.disease
Magnetic Resonance Imaging
Surgery
Parathyroid Hormone
Pediatrics, Perinatology and Child Health
Kidney Failure, Chronic
Calcium
business
Peritoneal Dialysis
medicine.drug
Calcification
Subjects
Details
- ISSN :
- 1432198X and 0931041X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....0057e14c1356225edbc645be6e43e9ca