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Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
- Source :
- Journal of alcoholism and drug dependence
- Publication Year :
- 2015
-
Abstract
- The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls).
- Subjects :
- Platelets
Neuro-Inflammation
business.industry
Cns function
Human immunodeficiency virus (HIV)
HIV
Alcohol
Alcohol users
Blood–brain barrier
Bioinformatics
medicine.disease_cause
Thrombocytopenia
Article
3. Good health
Neuro inflammation
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Immunology
medicine
Platelet
business
Cognitive impairment
Blood Brain Barrier
Subjects
Details
- Language :
- English
- ISSN :
- 23296488
- Volume :
- 3
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of alcoholism and drug dependence
- Accession number :
- edsair.doi.dedup.....004ef43ad005f59aa1d9e309c0bad18d