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Organic Cation Transporter–Mediated Clearance of Cardiovascular Drugs
- Source :
- American Journal of Therapeutics. 23:e855-e861
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- There exist a number of mechanisms to clear xenobiotics from human circulation. For cationic drugs, clearance is performed by human organic cation transporters 1 and 2 (hOCT1 and hOCT2), which are expressed in the liver and kidney, respectively. Given the prevalence of patients taking cardiovascular drugs, the present review focuses on the elimination of circulating cardiovascular drugs by organic cation transporters (OCTs). A significant number of cardiovascular drugs compete for transport by OCT1 or OCT2, introducing the potential to alter the pharmacokinetic profile of other concomitantly administered medications. The OCT system thereby represents an important site of drug-drug interactions.
- Subjects :
- 0301 basic medicine
Cardiotonic Agents
Organic Cation Transport Proteins
Pharmacology
030226 pharmacology & pharmacy
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pharmacokinetics
Ranolazine
Potassium Channel Blockers
Humans
Medicine
Ivabradine
Pharmacology (medical)
Organic cation transport proteins
biology
business.industry
Liver and kidney
Organic Cation Transporter 1
ORGANIC CATION TRANSPORTER 2
Organic Cation Transporter 2
General Medicine
Benzazepines
Calcium Channel Blockers
Adrenergic beta-1 Receptor Antagonists
030104 developmental biology
chemistry
biology.protein
business
Xenobiotic
Anti-Arrhythmia Agents
Sodium Channel Blockers
Subjects
Details
- ISSN :
- 10752765
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- American Journal of Therapeutics
- Accession number :
- edsair.doi.dedup.....00492455f277728bf5c3925daa9ca809