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Lomustine, vindesine and bleomycin (LVB) used in the treatment of relapsed advanced Hodgkin's disease. A prospective study on behalf of the east of Scotland and Newcastle lymphoma group (ESNLG)
- Source :
- Hematological Oncology. 7:77-86
- Publication Year :
- 1989
- Publisher :
- Wiley, 1989.
-
Abstract
- Sixty-three patients with relapsed advanced Hodgkin's disease were treated with lomustine (CCNU), vindesine and bleomycin (LVB). Age range was 17-72 years, with 38 males and 25 females. Thirty patients achieved complete remission (CR) with a median duration of 24+ months (range 3-55). Nineteen continue in unmaintained CR. CR rates were highest for those patients who relapsed greater than 6 months after first line treatment and for those at second or subsequent relapse. CR rates were higher in those with nodal only relapse. Twenty-seven patients were non-responders and six were partial responders. These 33 patients were subsequently changed to alternative chemotherapeutic regimes and 26 failed to respond to any therapy and have since died. Only one patient is in unmaintained complete remission. The regimen was well tolerated by patients, and easy to administer. It produced no serious episodes of toxicity. We conclude that LVB is of value in the management of relapsed advanced Hodgkin's disease especially in chronic relapsing patients, and where relapse occurs greater than 6 months after the first line treatment. We are presently unsure whether it offers any advantage over reintroduction of first line treatment in the latter group.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Adolescent
Vindesine
Subsequent Relapse
medicine.medical_treatment
Bleomycin
chemistry.chemical_compound
Lomustine
Recurrence
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Prospective Studies
Prospective cohort study
Aged
Chemotherapy
business.industry
Hematology
General Medicine
Middle Aged
medicine.disease
Hodgkin Disease
Lymphoma
Surgery
Regimen
Oncology
chemistry
Drug Evaluation
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 10991069 and 02780232
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Hematological Oncology
- Accession number :
- edsair.doi.dedup.....003d292493b3ce0d0e6e5012450fe8d7