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Expression of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) as a prognostic indicator in gastric cancer
- Source :
- European journal of cancer (Oxford, England : 1990). 42(1)
- Publication Year :
- 2005
-
Abstract
- In this study the expression levels of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) in gastric cancer cell lines and tissues have been analysed in order to assess their value as a prognostic indicator. The expressions of RECK, activated matrix metalloproteinase (MMP)-7, and vascular endothelial growth factor (VEGF) in gastric cancer tissues and cell lines were evaluated by Western blot analysis; and MMP-2 and MMP-9 were evaluated by gelatin zymography. RECK expression in the context of gastric cancer was also compared with various clinicopathologic parameters and compared to the expression of activated MMP-7, MMP-2, and MMP-9. Fifty-two percent of the 102 gastric cancer tissues and 81.8% of the 11 gastric cancer cell lines exhibited reduced RECK expression. We also detected a significant inverse correlation between RECK expression and macroscopic tumour growth (P = 0.018), lymphatic invasion (P = 0.018), lymph node metastasis (P = 0.000), stage (P = 0.000), and MMP-9 (P = 0.039). No correlation between RECK expression and MMP-7 and MMP-2, VEGF were detected. Our data strongly supports the hypothesis that RECK is a suppressor of malignancy, and constitutes a good prognostic indicator in gastric cancer.
- Subjects :
- Adult
Male
Vascular Endothelial Growth Factor A
Cancer Research
Pathology
medicine.medical_specialty
Blotting, Western
Context (language use)
Matrix metalloproteinase
Biology
GPI-Linked Proteins
Kazal Motifs
chemistry.chemical_compound
Stomach Neoplasms
Cell Line, Tumor
medicine
Humans
Stomach cancer
Aged
Membrane Glycoproteins
Cancer
Middle Aged
medicine.disease
Prognosis
Immunohistochemistry
Matrix Metalloproteinases
Neoplasm Proteins
Blot
Vascular endothelial growth factor
Oncology
chemistry
Cancer research
Female
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 42
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Accession number :
- edsair.doi.dedup.....003a497a3a2f3b47f4634c5e7fa517b6