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Repurposing the Selective Oestrogen Receptor Modulator Tamoxifen for the Treatment of Duchenne Muscular Dystrophy
- Source :
- CHIMIA, Vol 72, Iss 4 (2018)
- Publication Year :
- 2018
- Publisher :
- Swiss Chemical Society, 2018.
-
Abstract
- Drug discovery is a long, expensive and risky process. Evaluating drugs that have already been proved safe for use in humans and testing them for a new indication greatly reduces the time and monetary costs involved in finding treatments for life-threatening conditions. Here tamoxifen, a drug that is used for the treatment of breast cancer, is investigated in a mouse model of Duchenne muscular dystrophy. Tamoxifen was efficacious in countering the symptoms of the disease without affecting the underlying genetic cause. Based on these results, tamoxifen has been tested in other forms of muscle disease with success. Drug repurposing may not only be a cost-effective manner for treating a variety of diseases, it may also help us uncover common mechanisms between conditions that were previously thought to be unrelated.
- Subjects :
- Male
Selective Estrogen Receptor Modulators
Duchenne muscular dystrophy
0301 basic medicine
Disease
Bioinformatics
Serm
Mice
03 medical and health sciences
Breast cancer
medicine
Animals
Humans
Muscular dystrophy
QD1-999
Repurposing
business.industry
General Medicine
General Chemistry
medicine.disease
Muscular Dystrophy, Duchenne
Tamoxifen
Chemistry
Drug repositioning
030104 developmental biology
Oestrogens
Selective estrogen receptor modulator
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 26732424 and 00094293
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- CHIMIA
- Accession number :
- edsair.doi.dedup.....0032dc45f45ed16c2cfd26533744d698