Back to Search
Start Over
Evaluation of the Mycobacterium tuberculosis SO2 vaccine using a natural tuberculosis infection model in goats
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- The development of new vaccines against animal tuberculosis (TB) is a priority for improving the control and eradication of this disease, particularly in those species not subjected to compulsory eradication programmes. In this study, the protection conferred by the Mycobacterium tuberculosis SO experimental vaccine was evaluated using a natural infection model in goats. Twenty-six goats were distributed in three groups: (1) 10 goats served as a control group; (2) six goats were subcutaneously vaccinated with BCG; and (3) 10 goats were subcutaneously vaccinated with SO. Four months after vaccination, all groups were merged with goats infected with Mycobacterium bovis or Mycobacterium caprae, and tested over a 40 week period using a tuberculin intradermal test and an interferon-γ assay for mycobacterial reactivity. The severity of lesions was determined at post-mortem examination and the bacterial load in tissues were evaluated by culture. The two vaccinated groups had significantly lower lesion and bacterial culture scores than the control group (P<br />This research was funded by the Ministry of Economy and Competitiveness (MINECO, projects IPT-2012-0327-090000 and AGL2012-36171). Javier Bezos is a recipient of a Torres-Quevedo contract (PTQ-12-05812), funded by the MINECO and the European Social Fund.
- Subjects :
- 0301 basic medicine
Tuberculosis
Microbiological culture
040301 veterinary sciences
Tuberculin
Mycobacterium tuberculosis SO(2) vaccine
Caprine
0403 veterinary science
Lesion
Mycobacterium tuberculosis
03 medical and health sciences
medicine
Mycobacterium bovis
General Veterinary
biology
business.industry
04 agricultural and veterinary sciences
biology.organism_classification
medicine.disease
Mycobacterium caprae
Virology
Vaccination
Natural infection
030104 developmental biology
Animal Science and Zoology
medicine.symptom
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....00303df35912e680a76e985f328da42d