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Cerebral aspects of neonatal extracorporeal membrane oxygenation: a review
- Source :
- Neonatology, 104, 95-103, Neonatology, 104, 2, pp. 95-103
- Publication Year :
- 2013
-
Abstract
- Background: Neonatal extracorporeal membrane oxygenation (ECMO) is a lifesaving therapeutic approach in newborns suffering from severe, but potentially reversible, respiratory insufficiency, mostly complicated by neonatal persistent pulmonary hypertension. However, cerebral damage, intracerebral hemorrhage as well as ischemia belong to the most devastating complications of ECMO. Objectives: The objectives are to give insights into what is known from the literature concerning cerebral damage related to neonatal ECMO treatment for pulmonary reasons. Methods: A short introduction to ECMO indications and technical aspects of ECMO are provided for a better understanding of the process. The remainder of this review focuses on outcome and especially on (potential) risk factors for cerebral hemorrhage and ischemia during ECMO treatment. Results: Although neonatal ECMO treatment shows improved outcome compared to conservative treatment in cases of severe respiratory insufficiency, it is related to disturbances in various aspects of neurodevelopmental outcome. Risk factors for cerebral damage are either related to the patient's disease, EMCO treatment itself, or a combination of both. Conclusion: It is of ongoing importance to further understand pathophysiological mechanisms resulting in cerebral hemorrhage and ischemia due to ECMO and to develop neuroprotective strategies and approaches.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Ischemia
Brain damage
Disease
Severity of Illness Index
Brain Ischemia
Therapeutic approach
Child Development
Extracorporeal Membrane Oxygenation
Risk Factors
Severity of illness
medicine
Extracorporeal membrane oxygenation
Animals
Humans
Intensive care medicine
Cerebral Hemorrhage
Intracerebral hemorrhage
business.industry
Infant, Newborn
Functional imaging [IGMD 1]
medicine.disease
Treatment Outcome
surgical procedures, operative
Respiratory failure
Brain Injuries
Cerebrovascular Circulation
Anesthesia
Pediatrics, Perinatology and Child Health
medicine.symptom
Respiratory Insufficiency
business
Developmental Biology
Subjects
Details
- ISSN :
- 16617800
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Neonatology
- Accession number :
- edsair.doi.dedup.....0029dba98f94dc70e20ae2d10389ef2c