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Bactericidal genes of Staphylococcal bacteriophage Sb-1
- Source :
- Current microbiology. 68(2)
- Publication Year :
- 2013
-
Abstract
- Bacteriophage genes offer a potential resource for development of new antibiotics. Here, we identify at least six genes of Staphylococcus aureus phage Sb-1 that have bactericidal activity when expressed in Escherichia coli. Since the natural host is gram-positive, and E. coli is gram-negative, it is likely that a variety of quite different bacterial pathogens would be susceptible to each of these bactericidal activities, which therefore might serve as the basis for development of new wide-spectrum antibiotics. We show that two of these gene products target E. coli protein synthesis.
- Subjects :
- Staphylococcus aureus
Microbial Viability
Genes, Viral
medicine.drug_class
Antibiotics
Gene Expression
General Medicine
Biology
medicine.disease_cause
biology.organism_classification
Applied Microbiology and Biotechnology
Microbiology
Virology
Bacteriophage
Protein Biosynthesis
Protein biosynthesis
medicine
Cloning, Molecular
Staphylococcus Phages
Escherichia coli
Gene
Subjects
Details
- ISSN :
- 14320991
- Volume :
- 68
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Current microbiology
- Accession number :
- edsair.doi.dedup.....0025eef82cbd87ce4cbf6d8fe90c05d3