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Intrathecal Delivery of BDNF Into the Lumbar Cistern Re-Engages Locomotor Stepping After Spinal Cord Injury
- Source :
- IEEE Trans Neural Syst Rehabil Eng
- Publication Year :
- 2020
-
Abstract
- Delivery of neurotrophins to the spinal injury site via cellular transplants or viral vectors administration has been shown to promote recovery of locomotion in the absence of locomotor training in adult spinalized animals. These delivery methods involved risks of secondary injury to the cord and do not allow for precise and controlled dosing making them unsuitable for clinical applications. The present study was aimed at evaluating the locomotor recovery efficacy and safety of the neurotrophin BDNF delivered intrathecally to the lumbar locomotor centers using an implantable and programmable infusion mini-pump. Results showed that BDNF treated spinal cats recovered weight-bearing plantar stepping at all velocities tested (0.3-0.8 m/s). Spinal cats treated with saline did not recover stepping ability, especially at higher velocities, and dragged their hind paws on the treadmill. Histological evaluation showed minimal catheter associated trauma and tissue inflammation, underlining that intrathecal delivery by an implantable/programmable pump is a safe and effective method for delivery of a controlled BDNF dosage; it poses minimal risks to the cord and is clinically translational.
- Subjects :
- Cord
medicine.medical_treatment
Biomedical Engineering
Article
03 medical and health sciences
0302 clinical medicine
Lumbar
Internal Medicine
Medicine
Animals
Saline
Spinal cord injury
Spinal Cord Injuries
030304 developmental biology
Brain-derived neurotrophic factor
0303 health sciences
CATS
biology
business.industry
General Neuroscience
Brain-Derived Neurotrophic Factor
Rehabilitation
Recovery of Function
medicine.disease
Spinal cord
medicine.anatomical_structure
Spinal Cord
Anesthesia
biology.protein
Cats
Exercise Test
business
030217 neurology & neurosurgery
Locomotion
Neurotrophin
Subjects
Details
- ISSN :
- 15580210
- Volume :
- 28
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
- Accession number :
- edsair.doi.dedup.....00239d786f2e9f19fb52718b9a541749