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An Assessment of Gene-by-Environment Interactions in Developmental Dyslexia-Related Phenotypes
- Source :
- Europe PubMed Central
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- While the genetic and environmental contributions to developmental dyslexia (DD) have been studied extensively, the effects of identified genetic risk susceptibility and of specified environmental hazardous factors have usually been investigated separately. We assessed potential gene-by-environment (GxE) interactions on DD-related reading, spelling and memory phenotypes. The presence of GxE effects were investigated for the DYX1C1, DCDC2, KIAA0319 and ROBO1 genes, and for seven specified environmental moderators in 165 nuclear families in which at least one member had DD, by implementing a general test for GxE interaction in sib-pair-based association analysis of quantitative traits. Our results support a diathesis-stress model for both reading and memory composites: GxE effects were found between some specified environmental moderators (i.e. maternal smoke during pregnancy, birth weight and socio-economic status) and the DYX1C1-1259C/G marker. We have provided initial evidence that the joint analysis of identified genetic risk susceptibility and measured putative risk factors can be exploited in the study of the etiology of DD and reading-related neuropsychological phenotypes, and may assist in identifying/preventing the occurrence of DD.
- Subjects :
- Male
Nerve Tissue Proteins
Genetic Association Studie
Socioeconomic Factor
Polymorphism, Single Nucleotide
Dyslexia
Behavioral Neuroscience
Quantitative Trait, Heritable
M-PSI/04 - PSICOLOGIA DELLO SVILUPPO E PSICOLOGIA DELL'EDUCAZIONE
Memory
Pregnancy
Genetics
Humans
Child
Genetic Association Studies
Nuclear Protein
Nuclear Proteins
Cytoskeletal Proteins
Phenotype
Socioeconomic Factors
Neurology
Case-Control Studies
Prenatal Exposure Delayed Effects
Nerve Tissue Protein
Female
Gene-Environment Interaction
Tobacco Smoke Pollution
Case-Control Studie
Stress, Psychological
Human
Subjects
Details
- ISSN :
- 16011848
- Database :
- OpenAIRE
- Journal :
- Genes, Brain and Behavior
- Accession number :
- edsair.doi.dedup.....001ed150c0de91f63655efb1a690c084