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Prognostic significance of epidermal growth factor receptor expression in glioma patients
- Source :
- OncoTargets and therapy
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Junhong Li,* Ruofei Liang,* Chen Song, Yufan Xiang, Yanhui Liu Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People’s Republic of China *These authors contributed equally to this work Purpose: There is a great controversy regarding the prognostic significance of epidermal growth factor receptor (EGFR) in glioma patients. The current meta-analysis was conducted to evaluate the effect of abnormal EGFR expression on overall survival in glioma patients.Materials and methods: A comprehensive literature search of PubMed, EMBASE, Google Scholar, Web of Science, and Cochrane Library was conducted. The combined hazard ratio (HR) and its 95% confidence intervals (CIs) were used to evaluate the association between EGFR expression and survival in glioma.Results: A total of 476 articles were screened, and 17 articles containing 1,458 patients were selected. The quality assessment of the included studies was performed by the Newcastle–Ottawa Scale. Overexpression of EGFR was found to be an indicator of poor prognosis in overall survival in glioma patients (HR =1.72, 95% CI 1.32–2.25, P=0.000, random effect) and glioblastoma multiforme patients (HR =1.57, 95% CI 1.15–2.14, P=0.004, random effect). Subgroup analysis was conducted to explore the source of high heterogeneity.Conclusion: This meta-analysis indicated that high expression of EGFR may serve as a biomarker for poor prognosis in glioma patients. Keywords: epidermal growth factor receptor, glioma, meta-analysis, prognosis&nbsp
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Subgroup analysis
Cochrane Library
OncoTargets and Therapy
03 medical and health sciences
0302 clinical medicine
glioma
Internal medicine
Glioma
Medicine
Pharmacology (medical)
Epidermal growth factor receptor
Original Research
biology
business.industry
Hazard ratio
medicine.disease
Confidence interval
meta-analysis
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
biology.protein
Biomarker (medicine)
prognosis
epidermal growth factor receptor
business
Subjects
Details
- ISSN :
- 11786930
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- OncoTargets and Therapy
- Accession number :
- edsair.doi.dedup.....0006d85e3cd03360de38e12dc7f020c0