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Gut microbiota in patients after surgical treatment for colorectal cancer
- Source :
- Environmental Microbiology
- Publication Year :
- 2018
- Publisher :
- John Wiley & Sons, Inc., 2018.
-
Abstract
- Summary Colorectal cancer (CRC) is a common disease worldwide that is strongly associated with the gut microbiota. However, little is known regarding the gut microbiota after surgical treatment. 16S rRNA gene sequencing was used to evaluate differences in gut microbiota among colorectal adenoma patients, CRC patients, CRC postoperative patients and healthy controls by comparing gut microbiota diversity, overall composition and taxonomic signature abundance. The gut microbiota of CRC patients, adenoma patients and healthy controls developed in accordance with the adenoma‐carcinoma sequence, with impressive shifts in the gut microbiota before or during the development of CRC. The gut microbiota of postoperative patients and CRC patients differed significantly. Subdividing CRC postoperative patients according to the presence or absence of newly developed adenoma which based on the colonoscopy findings revealed that the gut microbiota of newly developed adenoma patients differed significantly from that of clean intestine patients and was more similar to the gut microbiota of carcinoma patients than to the gut microbiota of healthy controls. The alterations of the gut microbiota between the two groups of postoperative patients corresponded to CRC prognosis. More importantly, we used the different gut microbiota as biomarkers to distinguish postoperative patients with or without newly developed adenoma, achieving an AUC value of 0.72. These insights on the changes in the gut microbiota of CRC patients after surgical treatment may allow the use of the microbiota as non‐invasive biomarkers for the diagnosis of newly developed adenomas and to help prevent cancer recurrence in postoperative patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adenoma
Colorectal cancer
Colonoscopy
Colorectal adenoma
Gut flora
Microbiology
Gastroenterology
digestive system
03 medical and health sciences
Young Adult
fluids and secretions
Internal medicine
Carcinoma
medicine
Humans
Young adult
Ecology, Evolution, Behavior and Systematics
Research Articles
030304 developmental biology
Aged
Aged, 80 and over
0303 health sciences
biology
medicine.diagnostic_test
Bacteria
030306 microbiology
Gastrointestinal Microbiome
digestive, oral, and skin physiology
Middle Aged
medicine.disease
biology.organism_classification
digestive system diseases
Intestines
stomatognathic diseases
Female
Colorectal Neoplasms
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14622920 and 14622912
- Volume :
- 21
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Environmental Microbiology
- Accession number :
- edsair.doi.dedup.....00056a9d911971d9a8dba77d03f443fc