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Pulmonary histopathologic changes associated with melphalan therapy
- Source :
- Cancer. 42:1239-1245
- Publication Year :
- 1978
- Publisher :
- Wiley, 1978.
-
Abstract
- A case of fatal pulmonary fibrosis and atypical epithelial proliferation (AEP) in a patient with multiple myeloma treated with melphalan is presented. Review of 10 other autopsied patients with myeloma treated with melphalan but no thoracic radiation, other cytotoxic agents, or highdose oxygen therapy revealed one other patient who died with extensive pulmonary fibrosis and AEP. Four other patients with AEP not associated with pneumonitis or fibrosis were also found, while no such changes were found in 11 autopsy controls or 11 patients with myeloma who did not receive cytotoxic agents. Melphalan should be added to the growing list of agents capable of causing severe fibrotic pulmonary reactions.
- Subjects :
- Melphalan
Cancer Research
Pathology
medicine.medical_specialty
business.industry
medicine.medical_treatment
Autopsy
medicine.disease
Oncology
immune system diseases
Fibrosis
hemic and lymphatic diseases
Oxygen therapy
Pulmonary fibrosis
Medicine
Epithelial proliferation
business
Multiple myeloma
medicine.drug
Pneumonitis
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi...........ffdac612c3a23a241bf71b1719aa5fd7