ALTERNATIVE MACROPHAGES PROMOTE INTRAPLAQUE ANGIOGENESIS AND VASCULAR PERMEABILITY IN HUMAN ATHEROSCLEROSIS

Authors :: Liang Guo
Adrienne L. King
Hirokuni Akahori
Cheol Ung Choi
Qi Cheng
Vinit Karmali
Salim R. Thabet
Frank D. Kolodgie
Aloke V. Finn
Rohini Polavarapu
Renu Virmani
Hanjoong Jo
Source :: Journal of the American College of Cardiology. 67:2241
Publication Year :: 2016
Publisher :: Elsevier BV, 2016.
Abstract: Alternative macrophages exist in human atherosclerosis but their role in atherogenesis remains uncertain. Intraplaque hemorrhage (IPH) is an important stimulus driving alternative macrophage polarization. Intake of hemoglobin (Hb) by the hemoglobin: haptoglobin receptor CD163 leads to a distinct non

Subjects :: biology
business.industry
Angiogenesis
Haptoglobin
Macrophage polarization
Vascular permeability
Stimulus (physiology)
Cancer research
biology.protein
Medicine
Hemoglobin
Cardiology and Cardiovascular Medicine
business
Receptor
CD163

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