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ChemInform Abstract: The Isolation and Structure Elucidation of Zaragozic Acid C, a Novel Potent Squalene Synthase Inhibitor
- Source :
- ChemInform. 24
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The novel zaragozic acid C ( 1 ) has been isolated as a potent inhibitor of squalene synthase. It was found to be a competitive inhibitor of rat liver squalene synthase with an apparent K i of 45 ± 15 pM, and a broad spectrum antifungal agent against both yeast and filamentous fungi.
Details
- ISSN :
- 09317597
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........ffc06641a9439c79fb48e6b9a7ed8b67
- Full Text :
- https://doi.org/10.1002/chin.199308288