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Gestational changes in buprenorphine exposure: A physiologically-based pharmacokinetic analysis

Authors :
Jaime R. Bastian
Steve N. Caritis
Huijun Chen
Hongfei Zhang
Raman Venkataramanan
Ali Mohamed Alshabi
Hari V. Kalluri
Source :
British Journal of Clinical Pharmacology. 84:2075-2087
Publication Year :
2018
Publisher :
Wiley, 2018.

Abstract

Aims Buprenorphine (BUP) is approved by the US Food and Drug Administration for the treatment of opioid addiction. The current dosing regimen of BUP in pregnant women is based on recommendations designed for nonpregnant adults. However, physiological changes during pregnancy may alter BUP exposure and efficacy. The objectives of this study were to develop a physiologically-based pharmacokinetic (PBPK) model for BUP in pregnant women, to predict changes in BUP exposure at different stages of pregnancy, and to demonstrate the utility of PBPK modelling in optimizing BUP pharmacotherapy during pregnancy. Methods A full PBPK model for BUP was initially built and validated in healthy subjects. A fetoplacental compartment was included as a combined compartment in this model to simulate pregnancy induced anatomical and physiological changes. Further, gestational changes in physiological parameters were incorporated in this model. The PBPK model predictions of BUP exposure in pregnancy and during the postpartum period were compared to published data from a prospective clinical study. Results The predicted BUP plasma concentration-time profiles in the virtual pregnant populations are consistent with the observed data in the 2nd and 3rd trimesters, and the postpartum period. The differences in the predicted means of dose normalized area under the plasma drug concentration-time curve up to 12 h, average concentration and maximum concentration were within ±25% of the corresponding observed means with the exception of average concentration in the 3rd trimester (-26.3%). Conclusion PBPK model-based simulation may be a useful tool to optimize BUP pharmacotherapy during pregnancy, obviating the need to perform pharmacokinetic studies in each trimester and the postpartum period that normally require intensive blood sampling.

Details

ISSN :
03065251
Volume :
84
Database :
OpenAIRE
Journal :
British Journal of Clinical Pharmacology
Accession number :
edsair.doi...........ff9a1b07533d3802ad48c6010ed3a76e
Full Text :
https://doi.org/10.1111/bcp.13642