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Reduction Of Bile Acid Synthesis And Intrahepatic Lipid Accumulation In Liver-Humanized Mice Define The Unfavorable Pharmacodynamics Of Lxr Agonism In Humans

Authors :
Mirko E. Minniti
Katariina Öörni
Lise Lotte Vedin
Paolo Parini
Serge Luquet
Knut R. Steffensen
Elizabeth M. Wilson
John Bial
Matteo Pedrelli
Source :
Atherosclerosis. 287:e28-e29
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Subjects

Subjects :
Lipid accumulation
Chemistry
Pharmacodynamics
Pharmacology
Cardiology and Cardiovascular Medicine
Liver X receptor
Bile acid synthesis

Details

ISSN :
00219150
Volume :
287
Database :
OpenAIRE
Journal :
Atherosclerosis
Accession number :
edsair.doi...........ff8788617cca034094f63ab52a51d8aa

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