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Subharmonic and Endoscopic Contrast Imaging of Pancreatic Masses: A Pilot Study
- Source :
- Journal of Ultrasound in Medicine. 37:123-129
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objectives To use subharmonic imaging (SHI) to depict the vascularity of pancreatic masses compared to contrast-enhanced endoscopic ultrasound (EUS) and pathologic results. Methods Sixteen patients scheduled for biopsy of a pancreatic mass were enrolled in an Institutional Review Board–approved study. Pulse-inversion SHI (transmitting/receiving at 2.5/1.25 MHz) was performed on a LOGIQ 9 system (GE Healthcare, Milwaukee, WI) with a 4C transducer, whereas contrast harmonic EUS (transmitting/receiving at 4.7/9.4 MHz) was performed with a radial endoscope (GF-UTC180; Olympus Corporation, Tokyo, Japan) connected to a ProSound SSD α-10 scanner (Hitachi Aloka, Tokyo, Japan). Two injections of the contrast agent Definity (Lantheus Medical Imaging, North Billerica, MA) were administrated (0.3–0.4 and 0.6–0.8 mL for EUS and SHI, respectively). Contrast-to-tissue ratios (CTRs) in the mass and an adjacent vessel were calculated. Four physicians independently scored the images (benign to malignant) for diagnostic accuracy and inter-reader agreement. Results One patient dropped out before imaging, leaving 11 adenocarcinomas, 1 gastrointestinal stromal tumor with pancreatic infiltration, and 3 benign masses. Marked subharmonic signals were obtained in all patients, with intratumoral blood flow clearly visualized with SHI. Significantly greater CTRs were obtained in the masses with SHI than with EUS (mean ± SD, 1.71 ± 1.63 versus 0.63 ± 0.89; P = .016). There were no differences in the CTR in the surrounding vessels or when grouped by pathologic results (P > .60). The accuracies for contrast EUS and SHI were low (
- Subjects :
- Endoscopic ultrasound
Subharmonic
Radiological and Ultrasound Technology
medicine.diagnostic_test
Endoscope
business.industry
fungi
Contrast imaging
medicine.disease
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Vascularity
030220 oncology & carcinogenesis
Biopsy
Medical imaging
medicine
Pancreatic mass
Radiology, Nuclear Medicine and imaging
medicine.symptom
business
Nuclear medicine
Subjects
Details
- ISSN :
- 02784297
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Ultrasound in Medicine
- Accession number :
- edsair.doi...........ff6f65e60e21fb9a55a4c03945310335