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BRAF V600E-positive monomorphic epitheliotropic intestinal T-cell lymphoma complicating the course of hairy cell leukemia
- Source :
- OncoTargets and Therapy. 12:4807-4812
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Hairy cell leukemia (HCL) is an uncommon B-cell chronic lymphoproliferative disorder whose pathogenesis and recurrence are strictly dependent on the presence of the BRAF V600E mutant. A 65-year-old male presented a monomorphic epitheliotropic intestinal T-cell lymphoma (formerly enteropathy-associated T-cell lymphoma, type II) with HCL not responding to first-line induction with cladribine. The intestinal lymphoma bears the BRAF V600E mutant, which is the molecular hallmark of HCL, being implicated in its pathogenesis. The case is of interest, as it provides the first description of a BRAF V600E-positive intestinal T-cell lymphoma, along with immunohistochemical and molecular demonstration, occurring in concomitance with HCL. A novel digital PCR-base method for HCL disease assessment is also suggested.
- Subjects :
- 0301 basic medicine
Intestinal T-cell lymphoma
business.industry
Mutant
medicine.disease
Lymphoma
BRAF V600E
Pathogenesis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Oncology
hemic and lymphatic diseases
030220 oncology & carcinogenesis
Cancer research
medicine
Immunohistochemistry
Pharmacology (medical)
Hairy cell leukemia
Cladribine
business
medicine.drug
Subjects
Details
- ISSN :
- 11786930
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- OncoTargets and Therapy
- Accession number :
- edsair.doi...........ff666d2eff3da39468be0708574c4a6b