ESR1 and FSHR Gene Polymorphisms Influence Ovarian Response to FSH in Poor Responder Women with Normal FSH Levels

In COS (Controlled Ovarian Stimulation), individual response are highly variable. A number of studies have evaluated the ovarian response to FSH in women most often aged over 35 years and with high FSH level. But we see also a poor response to ovarian stimulation in young women (16; 16; 16;>16] for GRs. Our study show the involvement of ESR1 and FSHR polymorphisms and the multi-genic spectrum of ovarian response to gonadotropin in women with normal gonadotropin levels. Moreover, the poor response to FSH linked to the 307GG genotype was not associated with an increase in plasma FSH.