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Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent
- Source :
- Journal of Molecular Structure. 1134:386-394
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The present article describes the synthesis and biological studies in vitro of a novel silver complex with furosemide (Ag-FSE). Elemental, thermal and mass spectrometric analysis indicated a 1:1 metal/ligand composition, with the molecular formula AgC 12 H 10 ClN 2 O 5 S. Infrared and nuclear magnetic resonance studies suggest coordination of the ligand to the silver ion by the oxygen atoms of the carboxylate group. Additional Density Functional Theory (DFT) studies led to the proposition of the structure of the Ag-FSE complex. The antibacterial activities of the complex were primarily evaluated by antibiogram assays using the disc diffusion method and minimum inhibitory concentrations (MIC). Moreover, the mutagenicity of the complex was also evaluated to ensure that it is safe for subsequent application. The Ag-FSE complex has shown a significant in vitro antibacterial activity against Gram-positive Staphylococcus aureus (ATCC 25923), Gram negative Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853), and yeast Candida albicans (ATCC 90028). The absence of a mutagenic activity of Ag-FSE against Salmonella Typhimurium bacterial strains in the Ames assay is an extremely important finding for its future use as a drug in medicine.
- Subjects :
- biology
010405 organic chemistry
Ligand
Stereochemistry
Organic Chemistry
010402 general chemistry
Antimicrobial
medicine.disease_cause
biology.organism_classification
01 natural sciences
Combinatorial chemistry
In vitro
0104 chemical sciences
Analytical Chemistry
Ames test
Inorganic Chemistry
chemistry.chemical_compound
chemistry
medicine
Carboxylate
Candida albicans
Antibacterial activity
Escherichia coli
Spectroscopy
Subjects
Details
- ISSN :
- 00222860
- Volume :
- 1134
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Structure
- Accession number :
- edsair.doi...........ff40ef366a79a0c4144730f247f81c31