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Confidence Regions for Constrained Optima in Response-Surface Experiments
- Source :
- Biometrics. 39:759
- Publication Year :
- 1983
- Publisher :
- JSTOR, 1983.
-
Abstract
- The precision of the estimated optimum from a response-surface experiment is often indicated via a confidence region about the optimum. Sometimes, because of associated secondary responses, unconstrained optima produce unrealistic operating conditions, even when the true response surface is known. We consider confidence intervals for constrained optima for which the constraint function is known or separately estimated. An example from a cancer combination chemotherapy experiment illustrates the construction of such a region.
- Subjects :
- Statistics and Probability
Surface (mathematics)
Mathematical optimization
General Immunology and Microbiology
Applied Mathematics
Combination chemotherapy
General Medicine
Function (mathematics)
General Biochemistry, Genetics and Molecular Biology
Confidence interval
Constraint (information theory)
General Agricultural and Biological Sciences
Mathematics
Confidence region
Subjects
Details
- ISSN :
- 0006341X
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Biometrics
- Accession number :
- edsair.doi...........fef7a9466b7cbf931e66fc5bbfd73412