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Lipid-polymer hybrid nanoparticles for controlled delivery of hydrophilic and lipophilic doxorubicin for breast cancer therapy
- Source :
- International Journal of Nanomedicine. 14:4961-4974
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Background: Lipid polymer hybrid nanoparticles (LPHNPs) for the controlled delivery of hydrophilic doxorubicin hydrochloride (DOX.HCl) and lipophilic DOX base have been fabricated by the single step modified nanoprecipitation method. Materials and methods: Poly (D, L-lactide-co-glicolide) (PLGA), lecithin, and 1,2-distearoyl-Sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000 (DSPE-PEG 2000) were selected as structural components. Results: The mean particle size was 173-208 nm, with an encapsulation efficiency of 17.8±1.9 to 43.8±4.4% and 40.3±0.6 to 59. 8±1.4% for DOX.HCl and DOX base, respectively. The drug release profile was in the range 33-57% in 24 hours and followed the Higuchi model (R2=0.9867-0.9450) and Fickian diffusion (n
- Subjects :
- food.ingredient
Biocompatibility
Biophysics
Pharmaceutical Science
Bioengineering
macromolecular substances
02 engineering and technology
Polyethylene glycol
010402 general chemistry
01 natural sciences
Lecithin
Biomaterials
chemistry.chemical_compound
food
Drug Discovery
polycyclic compounds
medicine
Doxorubicin
Chemistry
Organic Chemistry
technology, industry, and agriculture
General Medicine
021001 nanoscience & nanotechnology
Controlled release
3. Good health
0104 chemical sciences
carbohydrates (lipids)
PLGA
Drug delivery
Doxorubicin Hydrochloride
0210 nano-technology
Nuclear chemistry
medicine.drug
Subjects
Details
- ISSN :
- 11782013
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi...........fef14536c48b070e5b195da19d2a7848