A phase I dose-escalation study of the novel gamma secretase inhibitor PF-03084014 in patients (pts) with advanced solid tumors

Authors :: Xiaoxi Zhang
Arvind Dasari
Sophia Randolph
Geoffrey I. Shapiro
Rachel Courtney
James M. Cleary
M. N. Shaik
Patricia LoRusso
Wells A. Messersmith
Source :: Journal of Clinical Oncology. 29:3100-3100
Publication Year :: 2011
Publisher :: American Society of Clinical Oncology (ASCO), 2011.
Abstract: 3100 Background: Aberrant Notch signaling is implicated in tumor genesis. Gamma secretase plays a key role in Notch-dependent signaling. The reversible, noncompetitive, selective gamma secretase in...

Subjects :: Cancer Research
Oncology
business.industry
Gamma Secretase Inhibitor PF-03084014
Notch signaling pathway
Dose escalation
Medicine
In patient
Pharmacology
business
Gamma secretase

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