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Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta
- Source :
- Blood. 95:2967-2974
- Publication Year :
- 2000
- Publisher :
- American Society of Hematology, 2000.
-
Abstract
- We have studied the effect of transforming growth factor beta (TGFbeta) on erythropoiesis in cultures from adult peripheral blood, using flow cytometric enumeration of fetal hemoglobin (HbF)-containing cells. TGFbeta caused a dramatic increase in the proportions of cells that accumulated HbF together with adult hemoglobin (HbA) (F+A+ cells). This highly significant (P
- Subjects :
- medicine.medical_specialty
biology
Cellular differentiation
medicine.medical_treatment
Immunology
Cell Biology
Hematology
Transforming growth factor beta
Biochemistry
Molecular biology
Cytokine
Endocrinology
Cell culture
Internal medicine
Fetal hemoglobin
medicine
biology.protein
Erythropoiesis
Progenitor cell
Erythroid Precursor Cells
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi...........feb4d9d772a4893bd334479880f15773