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A 24 h Delay in the Redox Response Distinguishes the most Severe Stroke Patients from Less Severe Stroke Patients
- Source :
- Journal of Neurology & Neurophysiology.
- Publication Year :
- 2016
- Publisher :
- OMICS Publishing Group, 2016.
-
Abstract
- Objective: Admission measures of stroke severity are often used to assess 30-90 day outcomes. Since some patients have a poor outcome by discharge, we sought to identify a biomarker that distinguishes severities as well as acute outcomes. Disruptions in the equilibrium of the redox system were used as an indicator of stroke severity and acute outcome. Methods: Oxidation reduction potential (ORP), a measure of the redox system, was assessed in plasma at admission and 24 h later in patients admitted with stroke symptoms (n=76). Overall differences in ORP between stroke patients and healthy controls were determined. Within stroke patients, changes in ORP as a function of hospital discharge status, modified Rankin scale and NIHSS were assessed using ANOVA and the ability to predict acute outcome in ischemic stroke patients based on ORP was compared to NIHSS using Receiver Operator Characteristics. Results: Stroke patients had higher ORP levels than healthy controls (p 146.6 mV at admission was associated with a 46 fold increased odds of a good acute outcome. Conclusion: ORP measured at admission identified patients which died or were discharged to hospice based on their lower ORP values. The lower ORP and subsequent increase 24 h later in the most severely affected patients may reflect a failure or a delay in engaging the redox system, a response that may, during acute stages, be beneficial.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Stroke patient
Receiver operating characteristic
business.industry
Severe stroke
medicine.disease
Surgery
03 medical and health sciences
030104 developmental biology
Modified Rankin Scale
Internal medicine
Ischemic stroke
Cardiology
Biomarker (medicine)
Medicine
cardiovascular diseases
Analysis of variance
business
Stroke
Subjects
Details
- ISSN :
- 21559562
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology & Neurophysiology
- Accession number :
- edsair.doi...........fe622bac44bdd0cde2dfe6130a2ca094