Synthesis and Antimicrobial Activity of Bis-1,2,3-triazole Based Chalcones

A series of bis-1,2,3-triazole based chalcones has been synthesized in high yields. The newly synthesized compounds are characterized by IR, NMR and mass spectroscopy. The combination of the pharmacologically active moieties in a single scaffold results in their synergistic effect and high antimicrobial activity against several bacterial and fungal strains. The compounds 4f, 4l, 4e, 4k, 4c, and 4i demonstrate potent antimicrobial activity at concentrations of 75 and 100 µg/mL.