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Common and Diverging Integrin Signals Downstream of Adhesion and Mechanical Stimuli and Their Interplay with Reactive Oxygen Species
- Publication Year :
- 2016
- Publisher :
- WORLD SCIENTIFIC, 2016.
-
Abstract
- The integrin family of adhesion receptors regulates basic functions of cells, and the signals they induce are altered in tumor cells. In this review we discuss how different integrin-dependent signals are generated during cell adhesion and by physical forces acting on cells. We also describe how reactive oxygen species are integral parts of integrin signaling and highlight a few important questions in the field. Answers to those may improve our understanding of integrins and their role in the development of cancer.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........fe066964b042ad4508e5f9f854591ea1