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The relevance of multiple sclerosis cortical lesions on cortical thinning and their clinical impact as assessed by 7.0-T MRI

The relevance of multiple sclerosis cortical lesions on cortical thinning and their clinical impact as assessed by 7.0-T MRI

Authors :
Ambica Mehndiratta
Jacob A. Sloane
Revere P. Kinkel
Elena Herranz
Eric C. Klawiter
Constantina A. Treaba
Valeria Barletta
Russell Ouellette
Caterina Mainero
Source :
Journal of Neurology. 268:2473-2481
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

This study aimed to investigate at 7.0-T MRI a) the role of multiple sclerosis (MS) cortical lesions in cortical tissue loss b) their relation to neurological disability. In 76 relapsing remitting and 26 secondary progressive MS patients (N = 102) and 56 healthy subjects 7.0-T T2*-weighted images were acquired for lesion segmentation; 3.0-T T1-weighted structural scans for cortical surface reconstruction/cortical thickness estimation. Patients were dichotomized based on the median cortical lesion volume in low and high cortical lesion load groups that differed by age, MS phenotype and degree of neurological disability. Group differences in cortical thickness were tested on reconstructed cortical surface. Patients were evaluated clinically by means of the Expanded Disability Status Scale (EDSS). Cortical lesions were detected in 96% of patients. White matter lesion load was greater in the high than in the low cortical lesion load MS group (p = 0.01). Both MS groups disclosed clusters (prevalently parietal) of cortical thinning relative to healthy subjects, though these regions did not show the highest cortical lesion density, which predominantly involved frontal regions. Cortical thickness decreased on average by 0.37 mm, (p = 0.002) in MS patients for each unit standard deviation change in white matter lesion volume. The odds of having a higher EDSS were associated with cortical lesion volume (1.78, p = 0.01) and disease duration (1.15, p

Details

ISSN :
14321459 and 03405354
Volume :
268
Database :
OpenAIRE
Journal :
Journal of Neurology
Accession number :
edsair.doi...........fdf4cfd367d6d13755707c14360549a8
Full Text :
https://doi.org/10.1007/s00415-021-10400-4