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An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line
- Source :
- Revista de Chimie. 71:140-144
- Publication Year :
- 2020
- Publisher :
- Revista de Chimie SRL, 2020.
-
Abstract
- pigenin (API) is a phytocompound belonging to the subclass of flavones that can be found in both functional foods as well as medicinal plants. Recent studies have assigned API antioxidant, anti-inflammatory, anti-spasmodic, anti-viral, anti-thrombotic, anti-angiogenic and chemopreventive potential in vitro on various cell lines and/or in experimental animal models. Apigenin-7-O-glucoside (API-7) is one of its main glycosides and can be commonly found in chamomile flowers, parsley, celery. The aim of this study was to evaluate the in vitro anti-proliferative and pro-apoptotic effects of API and its glycoside (apigenin-7-O-glucoside) against HeLa human cervical cancer cells. Results have shown that in the set experimental conditions both the aglycone as well as the heteroside elicit antiproliferative and pro-apoptotic potential against the screened cell line, the aglycone being more active than the heteroside.
- Subjects :
- biology
Process equipment
Materials Science (miscellaneous)
Process Chemistry and Technology
General Engineering
food and beverages
General Chemistry
General Medicine
biology.organism_classification
Molecular biology
General Biochemistry, Genetics and Molecular Biology
In vitro
HeLa
chemistry.chemical_compound
Glucoside
chemistry
Cervical carcinoma
Apigenin
Materials Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Line (text file)
Subjects
Details
- ISSN :
- 26688212 and 00347752
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Revista de Chimie
- Accession number :
- edsair.doi...........fde8b96b1fbb4989abb0358dd14dd260