Other Uterine Sarcomas

Beyond leiomyosarcoma, uterine sarcomas and tumors that contain “sarcoma” in the name (i.e., carcinosarcoma) are well-recognized biological entities. The three nonleiomyosarcoma tumors, (low-grade) endometrial stromal sarcoma, high-grade undifferentiated stromal sarcoma, and mixed Mullerian tumors including carcinosarcoma, are all very different from one another biologically. They are often omitted in discussions of soft tissue pathology as different groups of pathologists generally review such cases in expert centers than those who review soft tissue or bone tumors. Age distribution for adult uterine endometrial stromal tumors is shown in Fig. 21.1.