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Associations of urinary 8‐iso‐prostaglandin F 2α levels with all‐cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study
- Source :
- Alzheimer's & Dementia. 16:804-813
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Introduction Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α ) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort. Results Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence. Discussion Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Epidemiology
Population
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Developmental Neuroscience
Internal medicine
Medicine
Dementia
Vascular dementia
education
Prospective cohort study
education.field_of_study
business.industry
Health Policy
Incidence (epidemiology)
Hazard ratio
medicine.disease
Psychiatry and Mental health
030104 developmental biology
Cohort
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi...........fd894ae23c819333eafaff548c535879
- Full Text :
- https://doi.org/10.1002/alz.12081