Novel Digital Pathology Method for Computer-Aided Analysis of Histopathological Images Obtained from Dystrophic Muscle Biopsies

Background: Despite the introduction of a full range of genetic diagnostic tests and sophisticated techniques in modern pathology, interpretation of histopathological images obtained from muscle biopsies remains important in the daily practice of neuropathology since it can give indications of the severity and the rate of progression of neuromuscular disease. In this paper, we propose a simple and time saving method for quantitative assessment of severity of Duchenne Muscular Dystrophy (DMD) based on computer-aided analysis of histopathological images obtained from biopsies of dystrophic muscles.