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Evaluation of actinic cheilitis using fluorescence lifetime spectroscopy
- Source :
- SPIE Proceedings.
- Publication Year :
- 2016
- Publisher :
- SPIE, 2016.
-
Abstract
- Actinic cheilitis is a potentially malignant disorder that mostly affects the vermilion border of the lower lip and can lead to squamous cell carcinoma. Because of its heterogeneous clinical aspect, it is difficult to indicate representative biopsy area. Late diagnosis is a limiting factor of therapeutic possibilities available to treat oral cancer. The diagnosis of actinic cheilitis is mainly based on clinical and histopathological analysis and it is a time consuming procedure to get the results. Information about the organization and chemical composition of the tissues can be obtained using fluorescence lifetime spectroscopy techniques without the need for biopsy. The main targeted fluorophores are NADH (nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide), which have free and bound states, each one with different average lifetimes. The average lifetimes for free and bound NADH and FAD change according to tissue metabolic alterations and allow a quick and non-invasive clinical investigation of injuries and to help clinicians with the early diagnosis of actinic cheilitis. This study aims to evaluate the fluorescence lifetime parameters at the discrimination of three degrees of epithelial dysplasia, the most important predictor of malignant development, described in up to 100% of actinic cheilitis cases.
- Subjects :
- 0301 basic medicine
Flavin adenine dinucleotide
Epithelial dysplasia
medicine.medical_specialty
medicine.diagnostic_test
business.industry
Actinic cheilitis
Cancer
Nicotinamide adenine dinucleotide
medicine.disease
01 natural sciences
Dermatology
Fluorescence
010309 optics
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
medicine.anatomical_structure
chemistry
0103 physical sciences
Biopsy
medicine
Vermilion border
business
Subjects
Details
- ISSN :
- 0277786X
- Database :
- OpenAIRE
- Journal :
- SPIE Proceedings
- Accession number :
- edsair.doi...........fd4b74eeb8a0d806d4a9fbf3a28f6b66