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Visualization of endoplasmic reticulum viscosity in the liver of mice with nonalcoholic fatty liver disease by a near-infrared fluorescence probe
- Source :
- Chinese Chemical Letters. 32:3641-3645
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Nonalcoholic fatty liver disease (NAFLD) can cause serious liver damage. Early diagnosis and effective treatment of NAFLD can greatly improve treatment rates. The initiation and development of NAFLD has been closely linked to endoplasmic reticulum (ER) stress, which might cause ER viscosity variations. Therefore, if the internal relationship between ER viscosity and NAFLD is clarified, an effective approach for early diagnosis may result. Herein, we fabricated a novel near-infrared (NIR) fluorescence imaging probe, Er-V, for monitoring ER viscosity through a molecular rotor strategy. Er-V exhibited a strong NIR fluorescence signal (at 626 nm) when the environmental viscosity hindered the rotation of the malononitrile group. Using Er-V, we successfully observed a significant enhancement in viscosity in the liver of mice with NAFLD. Therefore, this imaging method based on Er-V is expected to provide a new approach for early detection and diagnosis of NAFLD.
- Subjects :
- Fluorescence-lifetime imaging microscopy
Chemistry
Endoplasmic reticulum
nutritional and metabolic diseases
Early detection
02 engineering and technology
General Chemistry
Near infrared fluorescence
010402 general chemistry
021001 nanoscience & nanotechnology
medicine.disease
01 natural sciences
digestive system diseases
0104 chemical sciences
Viscosity
Nonalcoholic fatty liver disease
Cancer research
medicine
Effective treatment
0210 nano-technology
Nir fluorescence
Subjects
Details
- ISSN :
- 10018417
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Chinese Chemical Letters
- Accession number :
- edsair.doi...........fd07b2c65708792e0632e8da91e9cd29