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An unexpected role of steroid on podocytes: from zebrafish to human nephrotic syndrome?
- Source :
- Kidney International. 95:1015-1017
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- In this issue of Kidney International, Jobst-Schwan et al. developed a zebrafish model of MAGI2-deficiency, which recapitulates findings of human nephrotic syndrome due to MAGI2 mutations. The authors use this model system to screen for drugs that might target and alleviate MAGI2-associated nephrotic syndrome pathways. The scientific context of this publication and the significance of its key findings are discussed in this commentary.
- Subjects :
- 0301 basic medicine
Kidney
biology
business.industry
030232 urology & nephrology
Context (language use)
Model system
Bioinformatics
biology.organism_classification
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Nephrology
medicine
business
Zebrafish
Nephrotic syndrome
Subjects
Details
- ISSN :
- 00852538
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Kidney International
- Accession number :
- edsair.doi...........fc9325a25cd2fe57fbb7f942057dc4e8