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Differential Cortical Oscillatory Patterns in Amputees With and Without Phantom Limb Pain

Authors :
Ali Reza ArmaniKian
Mohamad Javad Fatemi
Ali Khatibi
Javad Hatami
Reza Khosrowabadi
Zahra Bagheri
Source :
Basic and Clinical Neuroscience Journal. 14:171-184
Publication Year :
2023
Publisher :
Negah Scientific Publisher, 2023.

Abstract

Introduction: Phantom limb pain (PLP) as neuropathic pain affects the life of amputees. It is believed an efficient PLP treatment should consider the underlying neurological mechanisms. Hereby, we investigated brain activity in PLP and its relationships to the psychological and cognitive dimensions of chronic pain. We investigate differences in resting brain activities between amputees with and without pain. We hypothesize significant differences in the motor cortex and parietal cortex activity that are related to pain perception. Also, we hypothesize two groups have significant differences in cognitive and psychological components. Methods: Behavioral assessment (psychological status, life satisfaction, and pain level) and EEG signals of 19 amputees (12 without pain and 7 with pain) were recorded. Data were statistically compared between the two groups. Also, the association between behavioral and neurophysiological data was computed. Results: The results showed a significant decrease in the pain group for the beta and gamma waves, as well as, for the theta and delta waves in the posterior temporal on both sides, during the eye-open condition. The eyes-closed condition showed that the delta waves were decreased on the right side of the cortex. Also, data showed a significant difference in the correlation of pain features with brain waves between the two groups. Conclusion: Significant differences were mostly observed in regions related to pain perception rather than the motor cortex. This can be due to the learned strategies to deal with pain and the degree of pain. Results showed maladaptive cognitive processes had a relationship with brain wave activities. According to the result of brain wave activities, it seems that cognitive factors have a role in the experience of PLP rather than neuroplasticity through amputation.

Details

ISSN :
2008126X and 22287442
Volume :
14
Database :
OpenAIRE
Journal :
Basic and Clinical Neuroscience Journal
Accession number :
edsair.doi...........fc6fbf779cd3629ad553a17dfeb8d14d
Full Text :
https://doi.org/10.32598/bcn.2021.261.1