Back to Search
Start Over
The ‘double pituitary hot spot’ sign of skull base meningioma on gallium-68-labelled somatostatin analogue PET
- Source :
- Journal of Medical Imaging and Radiation Oncology. 57:680-683
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Gallium-68 ((68) Ga)-labelled somatostatin analogue imaging by positron emission tomography (PET) is increasingly replacing single photon (such as (111) In-labelled octreotide) imaging in the detection and staging of carcinoid and other neuroendocrine tumours. Among other tissues, pituitary uptake of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-octreotate (DOTA-TATE) and other somatostatin analogues is physiological. DOTA-TATE also accumulates in meningiomas, which have a high density of somatostatin receptor expression. The combination of pituitary and skull base meningioma uptake results in a characteristic 'double hot spot' appearance, which indicates the presence of a meningioma. This is a case of a middle-aged woman who underwent (68) Ga-DOTA-TATE PET for confirmation and staging of clinically suspected carcinoid tumour, in whom a skull base meningioma was incidentally discovered. With the increasing use of PET in the management of neuroendocrine tumours - and the not infrequent occurrence of meningiomas - the appearance of meningiomas on somatostatin analogue imaging should be one with which reporting clinicians are familiar.
- Subjects :
- Pathology
medicine.medical_specialty
medicine.diagnostic_test
Somatostatin receptor
business.industry
Octreotide
medicine.disease
nervous system diseases
Meningioma
Somatostatin Analogue
Somatostatin
Skull Base Meningioma
Oncology
Positron emission tomography
otorhinolaryngologic diseases
medicine
Radiology, Nuclear Medicine and imaging
Carcinoid tumour
business
Nuclear medicine
neoplasms
medicine.drug
Subjects
Details
- ISSN :
- 17549477
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Imaging and Radiation Oncology
- Accession number :
- edsair.doi...........fc65d0d297c0d5d266aa9add6f888a41