Effect of Early Inhaled Glucocorticoid Therapy on Lung Mechanics of Ventilator Dependent Preterm Infants † 1589

Systemic and inhaled dexamethasone treatments have been shown to improve lung mechanics in preterm infants with chronic lung disease. 253 infants were enrolled in a multicenter randomized, placebo-controlled, double-blind clinical trial of early administration of beclomethasone (40μg/kg/day, tapered over 4 weeks) or placebo given by metered dose inhaler and aerochamber® (Mongahan Medical Corp., Inc). These infants were < 33 wks GA and