Modeling the Precipitation of <scp>l</scp>-Glutamic Acid via Acidification of Monosodium Glutamate

A new insight for quantitative determination of the complex interaction of kinetics of reactive crystallization is gained by a study of the acidification of monosodium glutamate with hydrochloric acid in a semi-batch reactor. The dynamic equilibrium of the l-glutamic acid ions, their simultaneous presence in the solution, and the effect on the crystal size and size distribution are simulated using a mathematical model based on integration of the population balance equation with the crystallization kinetics and thermodynamics of the process. The model includes equations of chemical reactions, pH, nucleation, size-independent growth, and population balance. This allows a precise determination of the driving force for the reactive crystallization and the parameters of the nucleation and crystal growth rate expressions. The model considers the effect of the controlling parameters such as the rate of addition of the acid and the initial concentrations of ionic species and can be used to predict the concentrati...