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Effects of enteric-coated, low-dose aspirin on parameters of platelet function
- Source :
- Alimentary Pharmacology & Therapeutics. 16:1683-1688
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- SUMMARY Background : Aspirin is widely used as an anti-thrombotic drug; however, it has been suggested that enteric-coated formulations of aspirin may be less bioavailable and less effective as anti-thrombotic agents. Aim : To assess the effect of a formulation of enteric-coated, low-dose (81 mg) aspirin on serum generated thromboxane B2 and platelet aggregation in healthy subjects. Methods : Twenty-four subjects participated in a double-blind, randomized, placebo-controlled, parallel-group, multiple-dose study. Twelve subjects in each of two groups received a daily oral dose of enteric-coated aspirin (81 mg) or matching placebo for 7 days. Serum thromboxane B2 and platelet aggregation (using 1 mm arachidonic acid and 1 µg/mL collagen as agonists) were measured 1–3 days prior to day 1, on day 1 (prior to therapy) and 4 h after the last dose on day 7. Results : After seven daily doses of enteric-coated aspirin, the mean percentage inhibition from baseline of ex vivo generated serum thromboxane B2 was 97.4%, compared with a 7.8% increase after placebo treatment. The mean percentage inhibition of arachidonic acid- and collagen-induced platelet aggregation was 97.9% and 70.9%, respectively, following enteric-coated aspirin, compared with − 1.0% and 2.7%, respectively, after placebo. Conclusions : The anti-platelet effects of multiple, daily, low-dose aspirin (as assessed by inhibition of serum thromboxane B2 and platelet aggregation) are not adversely affected by enteric coating.
- Subjects :
- Aspirin
medicine.medical_specialty
Hepatology
business.industry
Gastroenterology
Pharmacology
Placebo
Enteric coating
Surgery
Thromboxane B2
chemistry.chemical_compound
chemistry
Oral administration
medicine
Platelet aggregation inhibitor
Pharmacology (medical)
Platelet
Arachidonic acid
business
medicine.drug
Subjects
Details
- ISSN :
- 02692813
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics
- Accession number :
- edsair.doi...........fb7be2a8778c3747f1687e40d9493663