Molecular Basis of Pancreas Development and Function

1. An Historical and Phylogenetic Perspective of Islet-Cell Development R.C. Heller, J. Jensen, O.D. Madsen, H.V. Petersen, P. Serup. 2. Glucose Signalling to Transcription Factors of the Insulin Gene D. Melloul. 3. beta-Cell Dysfunction and Chronic Hyperglycaemia J.L. Leahy. 4. Glucose Toxicity of the Pancreatic beta-cell C. Gleason, J. Harmon, V. Poitout, R.P. Robertson, G. Sacchi, Y. Tanaka, Phuong Oanh T. Tran. 5. The alpha-Cell and Regulation of Glucagon Gene Transcription W. Knepel. 6. The KATP Channel and the Sulfonylurea Receptor T. Miki, S. Seino, H. Yano. 7. Glucagon-Like Peptide-1: An Insulinotropic Hormone with Potent Growth Factor Actions at the Pancreatic Islets of Langerhans G.G. Holz, C.A. Leech. 8. Communication of Islet Cells: Molecules and Functions D. Bosco, P. Meda. 9. Soluble Factors Important for Pancreas Development P. Czernichow, R. Scharfmann. 10. Role of Mesenchymal-Epithelial Interactions in Pancreas Development C.A. Crisera, G.K. Gittes, A.S. Kadison, M.T. Longaker, T.S. Maldonado. 11. Homeodomain Proteins in Pancreas Development U. Ahlgren, H. Edlund. 12. bHLH Factors and Notch in Pancreatic Development L.E. Flores, R.S. Heller, J. Jensen, O.D. Madsen, P. Serup. 13. Identification, Biological Functions, and Contribution to Human Diabetes of Islet-Brain 1 C.Bonny, G. Waeber. 14. Pax4 and Pax6 in Islet Differentiation P. Gruss, Xunlei Zhou. 15. The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis M. Stoffel. 16. Regulation of PDX-1 Gene Expression M.A. Cissell, K. Gerrish, S. Samaras, R. Stein, C.V.E. Wright. 17. Mechanisms of Postnatal b-Cell Mass Regulation S. Bonner-Weir, G.C. Weir. 18. Genetic Models of Insulin Resistance: Alterations in b-Cell Biology C.R. Kahn, R.N. Kulkarni. 19. Clinical Consequences of Genetic Defects in b-Cell Genes J.C. Evans, T.M. Frayling, A.T. Hattersley. 20. Pathophysiology of Glut2 in Diabetes Mellitus B. Thorens. 21. Use of a Cre-LoxP Strategy in Mice to Determine the Cell-Specific Roles of Glucokinase in MODY-2 M.A. Magnuson, C. Postic. 22. Development of b-Cell Lines for Transplantation in Type 1 Diabetes Mellitus S. Efrat. 23. Gene Therapeutic Approaches for b-Cell Replacement G.M. Beattie, A. Hayek, F. Levine. Colour Figures. Index.