AN ETIOLOGIC STUDY OF HODGKIN'S DISEASE

In a recent publication 1 we have described a diphtheroid organism obtained in pure culture in four cases of Hodgkin's disease, and observed in three others. In order to determine the possibility of an etiologic relationship between this organism and the disease, the Macacus rhesus monkey has been used for inoculation experiments. While the experiments have been under way but a comparatively short time, histologic examination of a portion of a group of enlarged lymph-nodes, removed for transplantation to another animal, is of so encouraging a nature that a report seems justified. While we cannot yet claim that by the inoculation of the organism in question we have produced Hodgkin's disease (meaning the firm establishment of the organism in the animal and a continued and progressive enlargement of the general lymphadenoid tissue), we can say, that by repeated injections we have produced progressive enlargement of a single group of lymph-nodes which