Ultrasonic Assisted Nano-structures of Novel Organotin Supramolecular Coordination Polymers as Potent Antitumor Agents

The reaction of potassium tetracyanocupprate(I) with triethyltin bromide in presence of phenanthroline (Phen) and quinoxaline (Qox) in acetonitrile via ultrasonic radiation yielded two new nano-supramolecular coordination polymers (SCP) of the type: [Cu2(CN)4(Et3Sn)2(Phen)2] SCP1 and [Cu2(CN)3(Et3Sn)(Qox)] SCP2. The obtained polymers were characterized using elemental and thermal analyses, as well as FT-IR, UV–vis, fluorescence, 1H NMR, and MS spectroscopes. Spectral and analytical features led to the conclusion that both Phen and Qox behave as bidentate ligands and the proposed formulae of SCP1 and SCP2 have the bimetallic nature, in which the geometry around Cu(I) atoms in SCP1 is tetrahedral and planar trigonal. While in SCP2, the Cu(I) has a trigonal plane geometry. Thermal analysis studies indicated that both SCP1 and SCP2 are thermally stable up to 140 °C. Additional confirmation for the structures of SCP1 and SCP2 was obtained from density functional theory (DFT) and molecular mechanics (MM+) calculations. Transmission electron microscopy (TEM) images of SCP1 and SCP2 show regular spherical-like nano-sized particles in the range of 31.24–62.13 nm and 5.16–23.90 nm, respectively. The inhibitory anti-oxidant activities of both SCP1 and SCP2 were investigated using erythrocyte hemolysis and ABTS methods and their cytotoxicity activities towards different tumor cells were also studied by MTT assay. The results showed that both the two polymers have high inhibitory anti-oxidant activities and SCP2 exhibits a significant decrease in surviving fraction of these cancer cell lines compared to SCP1.