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Ion Channel Pharmacology for Pain Modulation
- Source :
- Concepts and Principles of Pharmacology ISBN: 9783030353612
- Publication Year :
- 2019
- Publisher :
- Springer International Publishing, 2019.
-
Abstract
- A large series of different ion channels have been identified and investigated as potential targets for new medicines for the treatment of a variety of human diseases, including pain. Among these channels, the voltage gated calcium channels (VGCC) are inhibited by drugs for the treatment of migraine, neuropathic pain or intractable pain. Transient receptor potential (TRP) channels are emerging as important pain transducers as they sense low pH media or oxidative stress and other mediators and are abundantly found at sites of inflammation or tissue injury. Low pH may also activate acid sensing ion channels (ASIC) and mechanical forces stimulate the PIEZO channels. While potent agonists of TRP channels due to their desensitizing action on pain transmission are used as topical applications, the potential of TRP antagonists as pain therapeutics remains an exciting field of investigation. The study of ASIC or PIEZO channels in pain signaling is in an early stage, whereas antagonism of the purinergic P2X3 channels has been reported to provide beneficial effects in chronic intractable cough. The present chapter covers these intriguing channels in great detail, highlighting their diverse mechanisms and broad potential for therapeutic utility.
- Subjects :
- 0301 basic medicine
Voltage-dependent calcium channel
business.industry
Purinergic receptor
Inflammation
Pharmacology
03 medical and health sciences
Transient receptor potential channel
030104 developmental biology
0302 clinical medicine
Neuropathic pain
Medicine
Intractable pain
medicine.symptom
business
030217 neurology & neurosurgery
Ion channel
Acid-sensing ion channel
Subjects
Details
- ISBN :
- 978-3-030-35361-2
- ISBNs :
- 9783030353612
- Database :
- OpenAIRE
- Journal :
- Concepts and Principles of Pharmacology ISBN: 9783030353612
- Accession number :
- edsair.doi...........fb1f53cc698725a50dd724c86bd7df8a
- Full Text :
- https://doi.org/10.1007/164_2019_336