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Molecular testing of sarcomas
- Source :
- Diagnostic Histopathology. 23:431-441
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Connective tissue tumours, particularly sarcomas, are rare and present as a variety of histological subtypes with diverse management protocols and have varied prognoses. Many of these tumours have specific cancer driver genetic alterations that can be leveraged for diagnostic purposes. For practical purposes, these tumours can be categorised as harbouring genetic alterations including chromosomal rearrangements, gene amplifications, single nucleotide substitutions, and complex genetic abnormalities. Herein we discuss different tumour subtypes with their associated genetic abnormalities that may be used in clinical practice, when interpreted in the context of the relevant clinical, histological and radiological information. The benefits of large scale sequencing studies of sarcoma are leading to new insights into sarcoma development and are providing a biological rationale for personalised medicine. Genomic profiling and other "omic" studies will likely play a fundamental part in the development of new diagnostic and predictive biomarkers in the near future.
- Subjects :
- 0301 basic medicine
Histology
Genomic profiling
Cancer
Context (language use)
Biology
medicine.disease
Bioinformatics
Pathology and Forensic Medicine
Clinical Practice
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
medicine
Fish
Sarcoma
Gene
Predictive biomarker
Subjects
Details
- ISSN :
- 17562317
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Diagnostic Histopathology
- Accession number :
- edsair.doi...........fb1cd476d39b72b367896666c23e3f79
- Full Text :
- https://doi.org/10.1016/j.mpdhp.2017.08.003