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Enhancing liver on a chip Complex In Vitro Model studies using label-free optical imaging

Authors :
Marina Marjanovic
Steve R. Hood
Darold R. Spillman
Edita Aksamitiene
Prabuddha Mukherjee
Jason E. Ekert
Aneesh Alex
Mantas Zurauskas
Stephen A. Boppart
Chi Zhang
Jindou Shi
BanuPriya Sridharan
Source :
Visualizing and Quantifying Drug Distribution in Tissue V.
Publication Year :
2021
Publisher :
SPIE, 2021.

Abstract

Recent advances in tissue engineering and microfabrication have led to development of novel Complex In Vitro models (CIVMs) that more closely mimic pathophysiological functions of human tissues and organs. CIVMs can provide deeper insights into the mechanisms of human disease and pharmacological properties of new drug candidates during early stages of development. In this study, a multimodal optical imaging platform was used for characterizing the structural and functional features of a liver-on-a-chip model (CN Bio Innovations, UK).

Details

Database :
OpenAIRE
Journal :
Visualizing and Quantifying Drug Distribution in Tissue V
Accession number :
edsair.doi...........fad036da6563efba34699d6524cd504a
Full Text :
https://doi.org/10.1117/12.2578531